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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
20.91
Human Site:
Y187
Identified Species:
51.11
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
Y187
Q
D
H
A
S
D
A
Y
T
A
L
L
S
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
Y180
Q
G
H
A
G
D
A
Y
T
A
M
L
S
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
Y187
Q
D
H
A
S
D
E
Y
T
T
M
L
S
S
I
Rat
Rattus norvegicus
NP_001100622
1515
174729
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
Y181
R
D
Q
A
N
D
V
Y
T
S
M
L
S
S
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
Y185
R
E
K
S
N
D
A
Y
T
S
M
L
S
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
Y185
R
Q
K
S
N
T
Y
Y
M
Q
M
L
A
T
S
Honey Bee
Apis mellifera
XP_393171
2183
252634
Y188
R
E
K
N
N
T
Y
Y
T
N
M
L
A
T
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
R182
E
S
I
L
T
G
K
R
E
Q
R
P
Q
D
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
L205
Q
L
F
E
A
R
K
L
L
R
P
I
L
Q
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
80
N.A.
73.3
0
N.A.
N.A.
53.3
N.A.
46.6
N.A.
13.3
26.6
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
86.6
0
N.A.
N.A.
80
N.A.
86.6
N.A.
53.3
66.6
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
40
10
0
30
0
0
20
0
0
20
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
30
0
0
0
50
0
0
0
0
0
0
0
10
10
% D
% Glu:
10
20
0
10
0
0
10
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
10
0
0
10
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
30
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
10
% I
% Lys:
0
0
30
0
0
0
20
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
10
0
0
0
10
10
0
10
70
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
60
0
0
0
0
% M
% Asn:
0
0
0
10
40
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% P
% Gln:
40
10
10
0
0
0
0
0
0
20
0
0
10
10
0
% Q
% Arg:
40
0
0
0
0
10
0
10
0
10
10
0
0
0
0
% R
% Ser:
0
10
0
20
20
0
0
0
0
20
0
0
50
50
10
% S
% Thr:
0
0
0
0
10
20
0
0
60
10
0
0
0
20
0
% T
% Val:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
30
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
20
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _